(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
PD-1|PD-L1-IN1
CAS: 1818314-88-3
Molecular Formula: C36H33ClN2O7
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid - Names and Identifiers
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C36H33ClN2O7 |
| Molar Mass | 641.11 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Boling Point | 817.5±65.0 °C(Predicted) |
| Solubility | DMSO : 125 mg/mL (194.97 mM; Need ultrasonic) |
| pKa | 2.03±0.40(Predicted) |
| Storage Condition | -20°C |
| Physical and Chemical Properties | Bioactive BMS-1166 is a new and effective inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM. |
| In vitro study | BMS-1166 was less toxic to the cell lines tested, preventing the interaction of soluble PD-L1 with the PD-1 receptor expressed on the cell surface. BMS-1166 attenuated PD-L1 inhibition of T cell receptor-mediated T lymphocyte activation. |
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.56 ml | 7.799 ml | 15.598 ml |
| 5 mM | 0.312 ml | 1.56 ml | 3.12 ml |
| 10 mM | 0.156 ml | 0.78 ml | 1.56 ml |
| 5 mM | 0.031 ml | 0.156 ml | 0.312 ml |
Last Update：2024-01-02 23:10:35
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid - Introduction
PD-1 | PD-L1-IN1 is an organic compound with the chemical formula C14H11N3O3S. The following is a description of the nature, use, method and safety information of PD-1 | PD-L1-IN1:
Nature:
PD-1 | PD-L1-IN1 is a solid, room temperature for white crystal. It has a melting point of 198-199 ° C. And is insoluble in water and slightly soluble in organic solvents.
Use:
PD-1 | PD-L1-IN1 is a kind of drug material, which is widely used in cancer treatment research. It can be used as a promising anticancer drug candidate with the potential to inhibit tumor growth, especially for breast cancer and colorectal cancer.
Preparation Method:
PD-1 | The preparation method of PD-L1-IN1 is generally realized by chemical synthesis. Specifically, a commonly used synthetic route is to obtain PD-1 PD-L1-IN1 by reacting BMS-275291 with sulfuryl chloride under appropriate reaction conditions.
Safety Information:
Nature:
PD-1 | PD-L1-IN1 is a solid, room temperature for white crystal. It has a melting point of 198-199 ° C. And is insoluble in water and slightly soluble in organic solvents.
Use:
PD-1 | PD-L1-IN1 is a kind of drug material, which is widely used in cancer treatment research. It can be used as a promising anticancer drug candidate with the potential to inhibit tumor growth, especially for breast cancer and colorectal cancer.
Preparation Method:
PD-1 | The preparation method of PD-L1-IN1 is generally realized by chemical synthesis. Specifically, a commonly used synthetic route is to obtain PD-1 PD-L1-IN1 by reacting BMS-275291 with sulfuryl chloride under appropriate reaction conditions.
Safety Information:
Last Update：2024-04-09 01:59:58
![(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid](http://res.chembk.com/assets/images/structure/1818314-88-3.gif)
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View History
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
5-Oxopyrrolidine-2-carboxylic acid 15-tetracosenyl ester
1-Piperazinecarbothioamide,4-(1-ethyl-1H-benzimidazol-2-yl)-N-(2-phenylethyl)-(9CI)
1-(4-bromo-2-methylphenyl)cyclopropane-1-carboxylic acid
diethyl 2-[(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)(phenyl)methyl]malonate
495407-19-7
2277-19-2
371251-54-6
102247-85-8
(S)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylaMino)-2-Methylpropyl)-2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxaMide
5-Oxopyrrolidine-2-carboxylic acid 15-tetracosenyl ester
1-Piperazinecarbothioamide,4-(1-ethyl-1H-benzimidazol-2-yl)-N-(2-phenylethyl)-(9CI)
1-(4-bromo-2-methylphenyl)cyclopropane-1-carboxylic acid
diethyl 2-[(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)(phenyl)methyl]malonate
495407-19-7
2277-19-2
371251-54-6
102247-85-8
(S)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylaMino)-2-Methylpropyl)-2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxaMide